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| blog:bpaddock:chronic_pain_suicidal_behavior_and_ideation_and_antiepileptic_drugs [2017/03/27 19:40] bpaddock Added reference to the original Cell paper. | blog:bpaddock:chronic_pain_suicidal_behavior_and_ideation_and_antiepileptic_drugs [2017/03/27 19:41] bpaddock Fixed link to Cell. | ||
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| Çagla Eroglu, Nicola J. Allen, Michael W. Susman, Nancy A. O' | Çagla Eroglu, Nicola J. Allen, Michael W. Susman, Nancy A. O' | ||
| - | Synapses are asymmetric cellular adhesions that are critical for nervous system development and function, but the mechanisms that induce their formation are not well understood. We have previously identified thrombospondin as an astrocyte-secreted protein that promotes central nervous system (CNS) synaptogenesis. Here, we identify the neuronal thrombospondin receptor involved in CNS synapse formation as α2δ-1, the receptor for the anti-epileptic and analgesic drug gabapentin. We show that the VWF-A domain of α2δ-1 interacts with the epidermal growth factor-like repeats common to all thrombospondins. | + | Synapses are asymmetric cellular adhesions that are critical for nervous system development and function, but the mechanisms that induce their formation are not well understood. We have previously identified thrombospondin as an astrocyte-secreted protein that promotes central nervous system (CNS) synaptogenesis. Here, we identify the neuronal thrombospondin receptor involved in CNS synapse formation as α2δ-1, the receptor for the anti-epileptic and analgesic drug gabapentin. We show that the VWF-A domain of α2δ-1 interacts with the epidermal growth factor-like repeats common to all thrombospondins. |
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